Ribociclib in combination with letrozole was added to the National Comprehensive Cancer Network ® Clinical Practice Guidelines in Oncology (NCCN Guidelines ®) as a category 1 option for HR+/HER2- postmenopausal metastatic breast cancer patients 5. In March 2017, the US Food and Drug Administration (FDA) approved Kisqali, in combination with any aromatase inhibitor, as a treatment for metastatic breast cancer. Additional regulatory filings are underway with other health authorities worldwide. This decision is applicable to all 28 European Union member states plus Iceland, Norway and Liechtenstein. Kisqali is taken in combination with continuous use of any aromatase inhibitor. Kisqali can be taken orally once-daily with or without food at a suggested starting dose of 600 mg (three 200 mg tablets) for three weeks, followed by one week off treatment. Globally approximately 250,000 women are diagnosed with advanced breast cancer each year 4. Up to one-third of patients with early-stage breast cancer will subsequently develop advanced disease, for which there is currently no cure 3. More than half of patients (55%) with measurable disease taking Kisqali plus letrozole experienced a tumor reduction of at least 30 percent 1. MONALEESA-2 enrolled 668 postmenopausal women with HR+/HER2- advanced or metastatic breast cancer who received no prior systemic therapy for their advanced breast cancer and showed that Kisqali plus letrozole, an aromatase inhibitor, reduced the risk of progression or death by 43% over letrozole alone (median PFS=25.3 months (95% CI: 23.0-30.3) vs. “I am encouraged that women in Europe living with HR+/HER2- advanced breast cancer may be treated in first-line with ribociclib in combination with letrozole, which demonstrated strong progression-free survival of more than two years in the pivotal MONALEESA-2 trial.” “Advanced breast cancer remains incurable, so it’s important to start with a powerful treatment option at initial diagnosis,” said Wolfgang Janni, MD, PhD, University of Ulm, MONALEESA-2 investigator. The opinion included a recommendation that allows oncologists the flexibility to prescribe Kisqali with any aromatase inhibitor (i.e., letrozole, anastrozole or exemestane) they deem most appropriate for their patient. “We are proud of our collaboration with study investigators and patients, which provides the medical community with an important new treatment option for women with advanced or metastatic breast cancer.”ĮU approval follows a positive opinion granted in June by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA), which was based on superior efficacy and demonstrated safety of Kisqali plus letrozole versus letrozole alone in the pivotal Phase III MONALEESA-2 trial. “This approval of Kisqali reinforces our recognized leadership in cancer research and our commitment to innovative targeted therapies,” said Bruno Strigini, CEO, Novartis Oncology.
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Submissions consisting of the following are considered incomplete and will be removed: Please read our new rules page for more in-depth rules. Please do not submit the same issue more than once within 24 hours. Do everything you can to reduce the effort of the wonderful folks offering to help you.Īfter solving your problem, please mark it as solved by clicking 'flair' and confirming the 'solved' tag. State everything you have tried and all the guides/tutorials/sites you have followed as well as why they were unsuccessful. Try to research your issue before posting, don't be vague. The subreddit is only for support with tech issues. Please include your system specs, such as Windows/Linux/Mac version/build, model numbers, troubleshooting steps, symptoms, etc. Live Chat ~Enter Discord~ Submission Guidelines So don't drain the battery it is bad for the lifespan of your UPS too.Check out our Knowledge Base, all guides are compiled by our Trusted Techs. Note: The UPS will also reset if the battery drains entirely, meaning you’ll have to redo this process. clickĪnother confirmation box will appear, asking you "Toggle Beep?". The fourth option should be "UPS Beep On / Off". Now, to stop the UPS beeping sound, find the "Control" icon in the left column.Ī new option box will open. You will also know if the "Not communicating with UPS" icon on the UPSilon 2000 dashboard has stopped flashing red. Now, your PC should be able to recognize your UPS. On the "Settings" page, find "General Settings" in the upper left corner.Ĭhange the "Communication Type" to Mega (USB) and click "OK". The program will not recognize your UPS immediately, so we need to browse around in its settings menu first. The application can only be unlocked after adding these items correctly, so please keep this form in a safe place. It may take some time to start.Īfter startup, you will be asked to provide your email address, company name, and serial number from the manual that came with UPS. The USB-A end (the normal USB port end) should be plugged into the PC. When finished, please restart your computer.Īfter restarting, connect the USB-B end (the square end) to the UPS. The program can be downloaded from Windows here.įirst, you need to download and install the program on your PC or laptop. It contains the serial number.Ī program called UPSilon 2000( Click here to download). The small certificate provided with the device. The USB-A to USB-B cable included with the device. You can perform the following operations to turn off the KSTAR UPS beep: (Of course, we don't want you to do this.) Below information is shared by one of our customer Andy Walker/Memeburn and we hope it will help. However, if you think it is annoying, you can also turn it off through the UPS software. Continuous beeping (every second or twice, and never stops): It usually indicates that the battery power of the UPS is very low and you should shut it down immediately.10 seconds beep: Inform the battery is in use, you should save your work and shut down the computer.Occasionally, a beep will sound: This means that the UPS is operating normally.However, UPSs can not talk and in order to provide users with active warnings about changing UPS and power supply conditions, UPS has audible sounds. UPS plays an important role on keeping IT equipment running continuously. In some cases, you'll see a Change language box, from which you can select a language other than English. The Quick details section contains helpful summary information, including the name and size of the download file and its date of publication. Most of these pages follow a standard format and include most of the sections described here. When you click a download item in the Download Center, you will be directed to the download details page for that download. What should I do if I can’t find what I am looking for?.Explore our samples and discover the things you can build. Get started with Microsoft developer tools and technologies. Get downloads and tools for Windows development Get SDKs and tools for managing and interacting with Azure services See which service packs are currently available from Microsoft Help and Support.Īmplify your play with Microsoft Windows Media Player, encoders, codecs, and other related downloads. Get the latest version of Microsoft DirectX, and find other important DirectX updates for your version of Windows.ĭownload service packs containing updates for system reliability, program compatibility, and security. If you are looking for downloads for the Windows operating system or for Microsoft Office, try using Windows Update, which helps you keep your computer up to date without requiring you to visit the Download Center. Note that almost all of the downloads available from these websites can also be found in the Microsoft Download Center however, the other Microsoft sites may offer services and information that you may not find in the Download Center. In this section, you will find links to other Microsoft websites that offer downloads. When you see the item you’re interested in, click the item link to find out more about downloading or purchasing it. The Filter option operates together with the original search term to narrow the scope of search results. Click a Filter option to narrow the list of items displayed in the search results. A list of Filter options on the left side of the page.Click the down arrow, and select a display order for the search results. A Sort by box on the right side of the page.An Editor's choice listing of products and downloads, which are recommendations based on the search term.On the Search results page, you may see the following: To search by keyword, at the top of the page, in the Search Download Center search box, type the word or words you wish to search for.
Font Book does not work with web-based font libraries such as Google Fonts.You also get limited options while trying to manage an individual macOS font.It offers fewer options to compare and contrast two different fonts/variations.Font Book lacks many smart organization and customization options.It’s when you’d start noticing some severe limitations with the Font Book utility. At first look, you may think the Font Book is enough.īut, then, you should understand that a designer needs to handle hundreds of fonts at best. You can also create smart collections using this utility. When you select a single font, it also shows a preview of how it looks. You can see the list of System and User-installed fonts and categorize them. As you can see, the latest version of Font Book brings a lot of handy features. So, macOS ships with a decent utility called Font Book.įont Book is the native font manager for macOS, offering you a platform to access/manage the fonts installed on the Mac. You may have to disable, group, and manage fonts in general. Quite simply, if you ask us.īut, you don’t always need all the fonts. Double-clicking on the font file will handle the installation for you. So, if you have a font with the extensions mentioned above, you can install it on macOS. macOS Mojave adds support for OpenType-SVG fonts. MacOS supports TrueType (.ttf), Variable TrueType (.ttf), TrueType Collection (.ttc), OpenType (.otf), and OpenType Collection (.ttc) fonts. Well, that’s why macOS allows you to install third-party fonts on your Mac. Apple recommends developers use fonts other than the standard ones we mentioned. You can’t make the best design using these fonts alone. But, as a designer or developer, these fonts are not enough. Of course, you can’t remove most of them if you use macOS Catalina or later. So, on an ideal day, you should not remove the mentioned fonts from macOS. As you can guess, these are some of the cleanest-looking fonts too. However, if you use the iWork suite, you need more fonts like Chalkboard, Optima, Baskerville, Papyrus, Futura, etc. The list includes fonts like AppleGothic, Arial, Comic Sans, Georgia, Impact, Tahoma, Times New Roman, Verdana, etc. However, only some of them are the most essential for the OS and most third-party apps to function correctly. The system ships with various fonts belonging to different categories. Just like every other Operating System, macOS requires many fonts to function. TL DR: the best Mac font managers right now But, how do you collect and manage the various fonts out there? You’re in the right place if you use a Mac for your design workflow. Picking the wrong font for even the right design can ruin the design altogether. What we are saying is this: fonts are essential. There is also a reason why you should not use Comic Sans in formal design. There is a reason why the New York Times and someone’s bio website do not use the same font. No matter what digital product you create, fonts make all the difference in the world. Editor’s Note: This article is being continously updated, with new updates being added to the list of top font managers. Think of solitaire in the same way you would about a game of chess. Practicing patience is the best tip for winning solitaire games. King card faces are generally required to occupy an empty slot on the game board.Īt the end, players must have four clean piles with a top card of two in whichever corresponding suite is necessary. Spider solitaire, for example, requires players to match suits of alternating colors into stacks. Which suits must be matched will depend on the game you’re playing. Your ultimate objective is to stack the four suits of cards in descending face-value from Ace followed by the king, down and through three and two. Once you’ve got up to speed with the rules of the variant(s) you're going to play, it's a great idea to put all your knowledge into practice by playing free online solitaire. Know the terms for the different card piles in the game.Don't clock watch when you're learning the game.Be patient and really think about each move you make.You can play many different types of solitaire card games online and each one demands that you play in a slightly (even if it's very subtle) different way.īut there are some tips you can use for any variant of solitaire: Some variants of solitaire allow the stockpile, where players draw new cards from when they have no available moves, to draw three cards in sequence rather than one. One of the key tips for playing solitaire is to know the rules for the version you're playing. They can only move cards under the restrictions provided. Game Play: The game involves dealing cards from a shuffled deck into a prescribed arrangement, from which the player attempts to reorder the deck by suit and rank.Game Objective: The ultimate objective of the game is to fill all piles with the cards in the deck.The Deal: There are four different types of piles in Solitaire: the Tableau, the Foundations, the Stock or “Hand” pile, and the Talon or “Waste”pile.This is done automatically when you play online Solitaire. Requirements: A standard Solitaire game uses one 52-card pack, and game play starts after the board is set up.Use these when playing any free Solitaire game online. While each type of Solitaire has its own unique play, there are some general instructions that guide each game. So choose your variation and start playing the best free online solitaire games! The Rules of Solitaireĭid you know that of the numerous variations of Solitaire, the most popular version is Klondike Solitaire? This version is so popular that what people refer to as “classic” Solitaire rules are in fact Klondike game rules. Whatever type of solitaire you want to play, we have you covered. Testing yourself and your solitaire skill foundations with free online solitaire not only gives you a chance to improve your understanding of this varied game, but it also gives you the experience you need to play live games. Solitaire is a game of skill that demands real thought to achieve a high score, often requiring that you think several steps ahead if you want to win with a solid time. Playing solitaire online is a great pastime that provides people with countless hours of fun all over the world. We feature more than a dozen different versions of the classic game, including Classic Solitaire, Spider Solitaire, Pyramid Solitaire, and Freecell Solitaire. So, you know that our free solitaire games are the best classic card games around. We created the Microsoft Solitaire Collection that comes pre-installed on Microsoft Windows. Because if anyone knows solitaire, it's us. If you're a solitaire enthusiast, you're in the right place.
Several of the Escape Pods had been jettisoned and they believed that the passengers had fled right after take off. Imperial troops proceeded to search the craft, finding no trace of any of the ship's occupants. The ship was pulled in by the Death Star's tractor beam and was taken into a landing bay. They followed a lone TIE Fighter to its base, the dreaded Death Star, the battle station that had destroyed Alderaan with its immensely powerful superlaser. The ship, blasting off into hyperspace on its way to Alderaan.Īs they arrived, they encountered a deadly meteor storm and no sign of the planet they were looking for. Obi-Wan Kenobi, Luke Skywalker and two droids, R2-D2 and C-3PO, boarded the ship.Īs the Millennium Falcon blasted off, it was momentarily chased by two Imperial Star Destroyers, which were in orbit above the planet. Solo agreed to offer them passage and they met in Docking Bay 94. There, he encountered exiled Jedi Knight Obi-Wan Kenobi and young Luke Skywalker, who sought safe passage to the planet Alderaan in order to send a message to Bail Organa. Han Solo used the Millennium Falcon for many years with his Wookiee co-pilot Chewbacca before he landed on the planet Tatooine. Sometime after the galaxy-wide conflict it became the property of Lando Calrissian, Baron Administrator of Cloud City, a mining colony on Bespin, who lost it in a game of sabacc to Han Solo, a smuggler who used the ship for many years. The Millennium Falcon went through several previous owners and names before and during the Clone Wars. Tee (PhD '68), Nov., 1966 ( Large photo)Įd Lightfoot (left) and Victor P. ( Large photo)īob Bird (left) and Roland Ragatz, circa 1964. Both Mike and Dick are Bascom Hill Society members and generous supporters of the College of Engineering. ( Large photo)Ĭhemical engineering alumni Mike Jensen (second from left) and Dick Antoine (right) with Bob Bird (left) and faculty member Jim Rawlings (second from right) in March 2001. Professors Lightfoot (left), Bird and Stewart, authors of Transport Phenomena, in 1960. Publisher John Wiley & Sons presented Bob Bird, Warren Stewart and Ed Lightfoot with special leather-bound copies of the 62nd (and last!) printing of the first edition of Transport Phenomena. The BSL Lecture was inaugurated in the fall of 2001 to honor the achievements of these outstanding chemical engineers. With new or revised discussions of such topics as two-phase systems, angular momentum, Taylor dispersion and turbulence, the revision promises to help prepare students well into the 21st century. In "retirement," the three authors found time to thoroughly revise BSL, the second edition of which appeared in the summer of 2001. The enduring strength of BSL is testimony to the vision and attention to detail of its authors. BSL has changed fundamentally the organizing principle in virtually all chemical engineering curricula worldwide. This textbook, referred to by generations of chemical engineers simply as BSL after its authors, would remain in print for 41 years and see five translations. From this beginning, they prepared the landmark textbook, Transport Phenomena, published in 1960 by John Wiley & Sons. Lightfoot stepped forward to develop an undergraduate course at the University of Wisconsin to integrate the teaching of fluid flow, heat transfer, and diffusion. 1.4 TransportWithinCells 37 1.4.1 TransportAcrossthe CellMembrane 37 1.4.2 TransportWithinthe Cell 42 1.5 TranscellularTransport 44 1.5.1 JunctionsBetweenCells 44 1.5.2 Epithelial Cells 45 1.5.3 EndothelialCells 47 1.6 PhysiologicalTransportSystems 48 1.6.1 CardiovascularSystem 49 1.6.2 RespiratorySystem 55 1.6.3 GastrointestinalTract 60 1.6.4. Following World War II, chemical engineers moved into a number of new areas in which problem definitions and solutions required a deeper knowledge of the fundamentals of transport phenomena than those provided in the textbooks on unit operations. Particularly in undergraduate education, underlying theories of mass, momentum and energy transfer were presented only to the extent necessary for a narrow range of applications. Transport Phenomena: A Landmark in Chemical Engineering EducationĪs the chemical engineering profession developed in the first half of the 20th century, the concept of "unit operations" arose as the natural organizing principle in educating chemical engineers. |
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